Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC3433869 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Li Shenyang S Nagothu Kiran K Ranganathan Gouri G Ali Syed M SM Shank Brian B Gokden Neriman N Ayyadevara Srinivas S Megyesi Judit J Olivecrona Gunilla G Chugh Sumant S SS Kersten Sander S Portilla Didier D
American journal of physiology. Renal physiology 20120523 3
Peroxisome proliferator-activated receptor-α (PPARα) activation attenuates cisplatin (CP)-mediated acute kidney injury by increasing fatty acid oxidation, but mechanisms leading to reduced renal triglyceride (TG) accumulation could also contribute. Here, we investigated the effects of PPARα and CP on expression and enzyme activity of kidney lipoprotein lipase (LPL) as well as on expression of angiopoietin protein-like 4 (Angptl4), glycosylphosphatidylinositol-anchored-HDL-binding protein (GPIHBP ...[more]