Ontology highlight
ABSTRACT:
SUBMITTER: Crea F
PROVIDER: S-EPMC3448442 | biostudies-other | 2011 Aug
REPOSITORIES: biostudies-other
Crea Francesco F Duhagon Maria Ana MA Farrar William L WL Danesi Romano R
Trends in pharmacological sciences 20110427 8
Pharmacogenomics in oncology holds the promise to personalize cancer therapy. However, its clinical application is still limited to a few genes, and, in the large majority of cancers, the correlation between genotype and clinical outcome has been disappointing. One possible explanation is that current pharmacogenomic studies do not take into account the emerging role of cancer stem cells (CSCs) in drug sensitivity and resistance. CSCs are a subpopulation of cells driven by specific signal-transd ...[more]