Dataset Information

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.

ABSTRACT: Epistatic interactions between killer cell immunoglobulin-like receptors (KIRs) and their cognate HLA class I ligands have important implications for reproductive success, antiviral immunity, susceptibility to autoimmune conditions and cancer, as well as for graft-versus-leukemia reactions in settings of allogeneic stem cell transplantation. Although CD8 T cells are known to acquire KIRs when maturing from naive to terminally differentiated cells, little information is available about the constitution of KIR repertoires on human CD8 T cells. Here, we have performed a high-resolution analysis of KIR expression on CD8 T cells. The results show that most CD8 T cells possess a restricted KIR expression pattern, often dominated by a single activating or inhibitory KIR. Furthermore, the expression of KIR, and its modulation of CD8 T-cell function, was independent of expression of self-HLA class I ligands. Finally, despite similarities in the stochastic regulation of KIRs by the bidirectional proximal promoter, the specificity of inhibitory KIRs on CD8 T cells was often distinct from that of natural killer cells in the same individual. The results provide new insight into the formation of KIR repertoires on human T cells.

SUBMITTER: Bjorkstrom NK

PROVIDER: S-EPMC3482857 | biostudies-other | 2012 Oct

REPOSITORIES: biostudies-other

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CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.

Björkström Niklas K NK Béziat Vivien V Cichocki Frank F Liu Lisa L LL Levine Jeffrey J Larsson Stella S Koup Richard A RA Anderson Stephen K SK Ljunggren Hans-Gustaf HG Malmberg Karl-Johan KJ

Blood 20120911 17

Epistatic interactions between killer cell immunoglobulin-like receptors (KIRs) and their cognate HLA class I ligands have important implications for reproductive success, antiviral immunity, susceptibility to autoimmune conditions and cancer, as well as for graft-versus-leukemia reactions in settings of allogeneic stem cell transplantation. Although CD8 T cells are known to acquire KIRs when maturing from naive to terminally differentiated cells, little information is available about the consti ...[more]

PMID: 22968455

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Dataset Information

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.

Publications

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.

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