Ontology highlight
ABSTRACT:
SUBMITTER: Teo I
PROVIDER: S-EPMC3491821 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Teo Ian I Toms Steve M SM Marteyn Benoit B Barata Teresa S TS Simpson Peter P Johnston Karen A KA Schnupf Pamela P Puhar Andrea A Bell Tracey T Tang Chris C Zloh Mire M Matthews Steve S Rendle Phillip M PM Sansonetti Philippe J PJ Shaunak Sunil S
EMBO molecular medicine 20120806 9
Intestinal pathogens use the host's excessive inflammatory cytokine response, designed to eliminate dangerous bacteria, to disrupt epithelial gut wall integrity and promote their tissue invasion. We sought to develop a non-antibiotic-based approach to prevent this injury. Molecular docking studies suggested that glycosylated dendrimers block the TLR4-MD-2-LPS complex, and a 13.6 kDa polyamidoamine (PAMAM) dendrimer glucosamine (DG) reduced the induction of human monocyte interleukin (IL)-6 by Gr ...[more]