Ontology highlight
ABSTRACT:
SUBMITTER: Caesar R
PROVIDER: S-EPMC3505865 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Caesar Robert R Reigstad Christopher S CS Bäckhed Helene Kling HK Reinhardt Christoph C Ketonen Maria M Lundén Gunnel Östergren GÖ Cani Patrice D PD Bäckhed Fredrik F
Gut 20120425 12
<h4>Background</h4>Obesity is associated with accumulation of macrophages in white adipose tissue (WAT), which contribute to the development of insulin resistance. Germ-free (GF) mice have reduced adiposity and are protected against diet-induced obesity,<h4>Objective</h4>To investigate whether the gut microbiota and, specifically, gut-derived lipopolysaccharide (LPS) promote WAT inflammation and contribute to impaired glucose metabolism.<h4>Method</h4>Macrophage composition and expression of pro ...[more]