Ontology highlight
ABSTRACT:
SUBMITTER: Verma S
PROVIDER: S-EPMC3510021 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Verma Suzie S Han Siew Ping SP Michael Magdalene M Gomez Guillermo A GA Yang Zhe Z Teasdale Rohan D RD Ratheesh Aparna A Kovacs Eva M EM Ali Radiya G RG Yap Alpha S AS
Molecular biology of the cell 20121010 23
The epithelial zonula adherens (ZA) is a specialized adhesive junction where actin dynamics and myosin-driven contractility coincide. The junctional cytoskeleton is enriched in myosin II, which generates contractile force to support junctional tension. It is also enriched in dynamic actin filaments, which are replenished by ongoing actin assembly. In this study we sought to pursue the relationship between actin assembly and junctional contractility. We demonstrate that WAVE2-Arp2/3 is a major nu ...[more]