Ontology highlight
ABSTRACT:
SUBMITTER: Santoro SW
PROVIDER: S-EPMC3510456 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Santoro Stephen W SW Dulac Catherine C
eLife 20121213
We have identified a replication-independent histone variant, Hist2h2be (referred to herein as H2be), which is expressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). Gain- and loss-of-function experiments demonstrate that changes in H2be expression affect olfactory function and OR representation in the adult olfactory epithelium. We show that H2BE exp ...[more]