Unknown

Dataset Information

0

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.


ABSTRACT: Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebusmurinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebusmurinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.

SUBMITTER: Canron MH 

PROVIDER: S-EPMC3510464 | biostudies-other | 2012

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6026335 | biostudies-literature
| S-EPMC6117395 | biostudies-literature
| S-EPMC8558257 | biostudies-literature
| S-EPMC7460339 | biostudies-literature
| S-EPMC2665075 | biostudies-literature
| S-EPMC6997403 | biostudies-literature
| S-EPMC8392020 | biostudies-literature
| S-EPMC3613356 | biostudies-literature
| S-EPMC4923719 | biostudies-literature
| S-EPMC2821914 | biostudies-literature