DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Lin X
PROVIDER: S-EPMC3518819 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Publications
DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease.
Lin Xiangmin X Cook Travis J TJ Zabetian Cyrus P CP Leverenz James B JB Peskind Elaine R ER Hu Shu-Ching SC Cain Kevin C KC Pan Catherine C Edgar John Scott JS Goodlett David R DR Racette Brad A BA Checkoway Harvey H Montine Thomas J TJ Shi Min M Zhang Jing J
Scientific reports 20121211
DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease, ...[more]
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