Ontology highlight
ABSTRACT:
SUBMITTER: Sakai J
PROVIDER: S-EPMC3525814 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Sakai Jiro J Li Jingyu J Subramanian Kulandayan K KK Mondal Subhanjan S Bajrami Besnik B Hattori Hidenori H Jia Yonghui Y Dickinson Bryan C BC Zhong Jia J Ye Keqiang K Chang Christopher J CJ Ho Ye-Shih YS Zhou Jun J Luo Hongbo R HR
Immunity 20121115 6
The regulation of actin dynamics is pivotal for cellular processes such as cell adhesion, migration, and phagocytosis and thus is crucial for neutrophils to fulfill their roles in innate immunity. Many factors have been implicated in signal-induced actin polymerization, but the essential nature of the potential negative modulators are still poorly understood. Here we report that NADPH oxidase-dependent physiologically generated reactive oxygen species (ROS) negatively regulate actin polymerizati ...[more]