New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.
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ABSTRACT:
SUBMITTER: Sillitoe I
PROVIDER: S-EPMC3531114 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Publications
New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.
Sillitoe Ian I Cuff Alison L AL Dessailly Benoit H BH Dawson Natalie L NL Furnham Nicholas N Lee David D Lees Jonathan G JG Lewis Tony E TE Studer Romain A RA Rentzsch Robert R Yeats Corin C Thornton Janet M JM Orengo Christine A CA
Nucleic acids research 20121129 Database issue
CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functio ...[more]
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