Ontology highlight
ABSTRACT:
SUBMITTER: Lucas D
PROVIDER: S-EPMC3536760 | biostudies-other | 2013
REPOSITORIES: biostudies-other
PloS one 20130103 1
A definitive consequence of the aging process is the progressive deterioration of higher cognitive functions. Defects in DNA repair mechanisms mostly result in accelerated aging and reduced brain function. DNA polymerase µ is a novel accessory partner for the non-homologous end-joining DNA repair pathway for double-strand breaks, and its deficiency causes reduced DNA repair. Using associative learning and long-term potentiation experiments, we demonstrate that Polµ(-/-) mice, however, maintain t ...[more]