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The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate.


ABSTRACT: Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.

SUBMITTER: Li L 

PROVIDER: S-EPMC3541655 | biostudies-other | 2013 Jan

REPOSITORIES: biostudies-other

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