Ontology highlight
ABSTRACT:
SUBMITTER: Wu JN
PROVIDER: S-EPMC3546152 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Cancer discovery 20121203 1
<h4>Unlabelled</h4>Although disordered chromatin organization has long been recognized as a feature of cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their relationships to transcription are only beginning to be understood. Cancer genome sequencing studies have revealed a novel theme: frequent mutation of epigenetic regulators. Among these, the ARID1A/BAF250A subunit of the SWI/SNF (BRG1-associated factors) chromatin remodeling complex has emerged as recur ...[more]