Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3552880 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Autophagy 20121126 2
Autophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of the cytoplasm for delivery to the lysosome. Phosphatidylinositol 3-phosphate (PtdIns3P) produced by the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is essential for canonical autophagosome formation. RAB5A, a small GTPase localized to early endosomes, has been shown to associate with the class III PtdIns3K complex, regulate its activity and promote autophagosome formation. However, little i ...[more]