Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC3653875 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhao Yuanbo Y Hu Jia J Miao Guangyan G Qu Liujing L Wang Zhenda Z Li Ge G Lv Ping P Ma Dalong D Chen Yingyu Y
PloS one 20130514 5
Autophagy and endoplasmic reticulum (ER) stress are both tightly regulated cellular processes that play central roles in various physiological and pathological conditions. Recent reports have indicated that ER stress is a potent inducer of autophagy. However, little is known about the underlying molecular link between the two processes. Here we report a novel human protein, transmembrane protein 208 (TMEM208) that can regulate both autophagy and ER stress. When overexpressed, TMEM208 impaired au ...[more]