Ontology highlight
ABSTRACT:
SUBMITTER: Firczuk H
PROVIDER: S-EPMC3564266 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Firczuk Helena H Kannambath Shichina S Pahle Jürgen J Claydon Amy A Beynon Robert R Duncan John J Westerhoff Hans H Mendes Pedro P McCarthy John Eg JE
Molecular systems biology 20130101
Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway. Among other non-intuitive outcomes, translation demonstrates a high degree of functional modularity and comprises a non-stoichiometric combination of proteins manifesting functional convergence on a shared maximal translation rate. In exponentially growing cells, polypeptide elongation (eEF1A, eEF2, and eEF3) exerts the stron ...[more]