Hedgehog signaling pathway in ovarian cancer.
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ABSTRACT:
SUBMITTER: Szkandera J
PROVIDER: S-EPMC3565315 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Publications
Hedgehog signaling pathway in ovarian cancer.
Szkandera Joanna J Kiesslich Tobias T Haybaeck Johannes J Gerger Armin A Pichler Martin M
International journal of molecular sciences 20130109 1
Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathw ...[more]
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