Unknown

Dataset Information

0

Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity.


ABSTRACT: Toll-like receptors (TLRs) are traditionally associated with immune-mediated host defense. Here, we ascribe a novel extra-immune, hypothalamic-associated function to TLR2, a TLR-family member known to recognize lipid components, in the protection against obesity. We found that TLR2-deficient mice exhibited mature-onset obesity and susceptibility to high-fat diet (HFD)-induced weight gain, via modulation of food intake. Age-related obesity was still evident in chimeric mice, carrying comparable TLR2(+) immune cells, suggesting a non-hematopoietic-related involvement of this receptor. TLR2 was up-regulated with age or HFD in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus, a brain area participating in central-metabolic regulation, possibly modulating the hypothalamic-anorexigenic peptide, α-melanocyte-stimulating hormone (α-MSH). Direct activation of TLR2 in a hypothalamic-neuronal cell-line via its known ligands, further supports its capacity to mediate non-immune related metabolic regulation. Thus, our findings identify TLR2 expressed by hypothalamic neurons as a potential novel regulator of age-related weight gain and energy expenditure.

SUBMITTER: Shechter R 

PROVIDER: S-EPMC3570778 | biostudies-other | 2013

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC2782475 | biostudies-literature
| S-EPMC4611721 | biostudies-other
2023-11-10 | GSE246176 | GEO
| S-EPMC5086849 | biostudies-other
| S-EPMC5516014 | biostudies-literature
| S-EPMC2234214 | biostudies-literature
| S-EPMC8113522 | biostudies-literature
| S-EPMC2656656 | biostudies-literature
2015-05-18 | E-GEOD-58952 | biostudies-arrayexpress
| S-EPMC6317738 | biostudies-literature