Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC3574906 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Yang Shuo S Damiano Marina G MG Zhang Heng H Tripathy Sushant S Luthi Andrea J AJ Rink Jonathan S JS Ugolkov Andrey V AV Singh Amareshwar T K AT Dave Sandeep S SS Gordon Leo I LI Thaxton C Shad CS
Proceedings of the National Academy of Sciences of the United States of America 20130123 7
New therapies that challenge existing paradigms are needed for the treatment of cancer. We report a nanoparticle-enabled therapeutic approach to B-cell lymphoma using synthetic high density lipoprotein nanoparticles (HDL-NPs). HDL-NPs are synthesized using a gold nanoparticle template to control conjugate size and ensure a spherical shape. Like natural HDLs, biomimetic HDL-NPs target scavenger receptor type B-1, a high-affinity HDL receptor expressed by lymphoma cells. Functionally, compared wit ...[more]