Ontology highlight
ABSTRACT:
SUBMITTER: Gupta R
PROVIDER: S-EPMC3575820 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Nucleic acids research 20130107 4
Mycobacteria have two genetically distinct pathways for the homology-directed repair of DNA double-strand breaks: homologous recombination (HR) and single-strand annealing (SSA). HR is abolished by deletion of RecA and reduced in the absence of the AdnAB helicase/nuclease. By contrast, SSA is RecA-independent and requires RecBCD. Here we examine the function of RecO in mycobacterial DNA recombination and repair. Loss of RecO elicits hypersensitivity to DNA damaging agents similar to that caused ...[more]