Ontology highlight
ABSTRACT:
SUBMITTER: Patel V
PROVIDER: S-EPMC3581900 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Patel Vainav V Jalah Rashmi R Kulkarni Viraj V Valentin Antonio A Rosati Margherita M Alicea Candido C von Gegerfelt Agneta A Huang Wensheng W Guan Yongjun Y Keele Brandon F BF Bess Julian W JW Piatak Michael M Lifson Jeffrey D JD Williams William T WT Shen Xiaoying X Tomaras Georgia D GD Amara Rama R RR Robinson Harriet L HL Johnson Welkin W Broderick Kate E KE Sardesai Niranjan Y NY Venzon David J DJ Hirsch Vanessa M VM Felber Barbara K BK Pavlakis George N GN
Proceedings of the National Academy of Sciences of the United States of America 20130128 8
We have previously shown that macaques vaccinated with DNA vectors expressing SIVmac239 antigens developed potent immune responses able to reduce viremia upon high-dose SIVmac251 challenge. To further improve vaccine-induced immunity and protection, we combined the SIVmac239 DNA vaccine with protein immunization using inactivated SIVmac239 viral particles as protein source. Twenty-six weeks after the last vaccination, the animals were challenged intrarectally at weekly intervals with a titrated ...[more]