Ontology highlight
ABSTRACT:
SUBMITTER: Beeler JF
PROVIDER: S-EPMC358453 | biostudies-other | 1994 Feb
REPOSITORIES: biostudies-other
Beeler J F JF LaRochelle W J WJ Chedid M M Tronick S R SR Aaronson S A SA
Molecular and cellular biology 19940201 2
Screening of a human embryonic lung fibroblast cDNA expression library with antiphosphotyrosine antibodies led to isolation of a novel protein kinase. A clone, designated A6, contained a 3-kb cDNA insert with a predicted open reading frame of 350 amino acids. DNA sequence analysis failed to reveal any detectable similarity with previously known genes, and the predicted A6 protein lacked any of the motifs commonly conserved in the catalytic domains of protein kinases. However, the bacterially exp ...[more]