Ontology highlight
ABSTRACT:
SUBMITTER: Hayase J
PROVIDER: S-EPMC3587828 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Hayase Junya J Kamakura Sachiko S Iwakiri Yuko Y Yamaguchi Yoshihiro Y Izaki Tomoko T Ito Takashi T Sumimoto Hideki H
The Journal of cell biology 20130225 5
Formation of apico-basal polarity in epithelial cells is crucial for both morphogenesis (e.g., cyst formation) and function (e.g., tight junction development). Atypical protein kinase C (aPKC), complexed with Par6, is considered to translocate to the apical membrane and function in epithelial cell polarization. However, the mechanism for translocation of the Par6-aPKC complex has remained largely unknown. Here, we show that the WD40 protein Morg1 (mitogen-activated protein kinase organizer 1) di ...[more]