FIP200 regulates targeting of Atg16L1 to the isolation membrane.
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ABSTRACT:
SUBMITTER: Nishimura T
PROVIDER: S-EPMC3589088 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Publications
FIP200 regulates targeting of Atg16L1 to the isolation membrane.
Nishimura Taki T Kaizuka Takeshi T Cadwell Ken K Sahani Mayurbhai H MH Saitoh Tatsuya T Akira Shizuo S Virgin Herbert W HW Mizushima Noboru N
EMBO reports 20130208 3
Autophagosome formation is a dynamic process that is strictly controlled by autophagy-related (Atg) proteins. However, how these Atg proteins are recruited to the autophagosome formation site or autophagic membranes remains poorly understood. Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner. Atg16L1 deletion mutants, which lack the FIP200-interact ...[more]
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