Ontology highlight
ABSTRACT:
SUBMITTER: Dollard C
PROVIDER: S-EPMC359041 | biostudies-other | 1994 Aug
REPOSITORIES: biostudies-other
Dollard C C Ricupero-Hovasse S L SL Natsoulis G G Boeke J D JD Winston F F
Molecular and cellular biology 19940801 8
The Saccharomyces cerevisiae genome contains four loci that encode histone proteins. Two of these loci, HTA1-HTB1 and HTA2-HTB2, each encode histones H2A and H2B. The other two loci, HHT1-HHF1 and HHT2-HHF2, each encode histones H3 and H4. Because of their redundancy, deletion of any one histone locus does not cause lethality. Previous experiments demonstrated that mutations at one histone locus, HTA1-HTB1, do cause lethality when in conjunction with mutations in the SPT10 gene. SPT10 has been s ...[more]