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A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression.

ABSTRACT: AKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphatases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin.

SUBMITTER: Jurado S

PROVIDER: S-EPMC2943866 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression.

Jurado Sandra S Biou Virginie V Malenka Robert C RC

Nature neuroscience 20100808 9

AKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphatases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin. ...[more]

PMID: 20694001

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