STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.
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ABSTRACT:
SUBMITTER: Howell BW
PROVIDER: S-EPMC359671 | biostudies-other | 1991 Jan
REPOSITORIES: biostudies-other
Publications
STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.
Howell B W BW Afar D E DE Lew J J Douville E M EM Icely P L PL Gray D A DA Bell J C JC
Molecular and cellular biology 19910101 1
We have cloned a novel kinase (STY) from an embryonal carcinoma cell line. Sequence analysis of the STY cDNA reveals that it shares sequence homology with serine/threonine-type kinases and yet the bacterial expression product of the STY cDNA appears to have serine-, threonine-, and tyrosine-phosphorylating activities. The predicted STY protein is highly basic and contains a putative nuclear localization signal. During differentiation, two new mRNAs were detected in addition to the embryonic tran ...[more]
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