Ontology highlight
ABSTRACT:
SUBMITTER: Chen PK
PROVIDER: S-EPMC3605335 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Chen Po-Kong PK Chang Hsin-Hou HH Lin Guan-Ling GL Wang Tsung-Pao TP Lai Yi-Ling YL Lin Ting-Kai TK Hsieh Ming-Chun MC Kau Jyh-Hwa JH Huang Hsin-Hsien HH Hsu Hui-Ling HL Liao Chi-Yuan CY Sun Der-Shan DS
PloS one 20130321 3
Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear. LT inhibits cellular mitogen-activated protein kinases (MAPKs), which are vital pathways responsible for cell survival, differentiation, and maturation. One of the MAPKs, the MEK1/2-extracellular signal-regulated kinase pathway, is particularly important in megakaryopoiesis. Thi ...[more]