Impossible or merely difficult? Two grand challenges from a biologist's perspective.
Ontology highlight
ABSTRACT:
SUBMITTER: Roth BL
PROVIDER: S-EPMC3609670 | biostudies-other | 2013
REPOSITORIES: biostudies-other
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Project description:Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistication with the ability to monitor human health in both non-invasive and invasive modes. The multiple scales at which human physiology can be interrogated provide a profound perspective on health and disease. We are at the nexus of creating "avatars" (herein defined as an extension of "digital twins") of human patho/physiology to serve as paradigms for interrogation and potential intervention. Motivated by the emergence of these new capabilities, the IEEE Engineering in Medicine and Biology Society, the Departments of Biomedical Engineering at Johns Hopkins University and Bioengineering at University of California at San Diego sponsored an interdisciplinary workshop to define the grand challenges that face biomedical engineering and the mechanisms to address these challenges. The Workshop identified five grand challenges with cross-cutting themes and provided a roadmap for new technologies, identified new training needs, and defined the types of interdisciplinary teams needed for addressing these challenges. The themes presented in this paper include: 1) accumedicine through creation of avatars of cells, tissues, organs and whole human; 2) development of smart and responsive devices for human function augmentation; 3) exocortical technologies to understand brain function and treat neuropathologies; 4) the development of approaches to harness the human immune system for health and wellness; and 5) new strategies to engineer genomes and cells.
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Project description:Highlights • Complex socio-technical challenges lack a method for their holistic framing.• Existent problem-framing methods are biased in favor of expert opinion.• CSFA provides a pattern-based ontological frame for complex problems.• System user data can be valuably mined to aid experts with problem-framing.• CSFA yields frames with improved coverage of plurality, abstraction, context and scope. Complex socio-technical challenges, often referred to as grand challenges or wicked problems, lack a robust method for their holistic framing. Current approaches to framing fall into two primary categories. On one hand, models grounded in reductionist perspectives tend to oversimplify the problems and thus fall short of capturing the true complexity that must be understood to make tangible progress. On the other, notable attempts to achieve holism are more effective at incorporating contextual nuance, but still lack systematicity to identify and drive effective inclusion of critical issues, and also tend to suffer from the inherent bias of select expert input. In this article, we report on an extension of holistic problem framing techniques called comprehensive success factor analysis (CSFA) that makes-sense of web-mined information reflective of both expert and general population perspectives as well as pattern-informed ontological knowledge organization structure, to yield ‘richer pictures’ of grand challenges. This method has been developed and refined over a seven-year period by application to a variety of distinct socio-technical challenges, and emphasizes that framing complex problems requires one to embrace multiple levels of abstraction, a plurality of perspectives, careful contextualization, and an overarching system view. The CSFA method results in ‘success factor trees’ that are more comprehensive than seen otherwise and present a holistic view of the essential factors that need to be considered when engaging in large scale socio-technical problems. The success factor trees provide common grounds for meaningful collaboration and discourse on grand challenges, facilitate more informed resource allocation decisions, and provide guidance for designing solutions through careful consideration of system factors that are not always apparent. The paper illustrates CSFA applied to the challenge of ‘food security for a nation in a low- to middle-income country context’ to ascertain the value of the approach and finds that it results in a robust view of the challenge that greatly exceeds perspectives arrived at in the literature using current framing methods, on dimensions of scope, levels of abstraction, plurality, and context detail. Graphical abstract Image, graphical abstract
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Project description:This article analyzes the concept of "grand challenges" as part of a shift in how scientists and policymakers frame and communicate their respective agendas. The history of the grand challenges discourse helps to understand how identity work in science and science policy has been transformed in recent decades. Furthermore, the question is raised whether this discourse is only an indicator, or also a factor in this transformation. Building on conceptual history and historical semantics, the two parts of the article reconstruct two discursive shifts. First, the observation that in scientific communication references to "problems" are increasingly substituted by references to "challenges" indicates a broader cultural trend of how attitudes towards what is problematic have shifted in the last decades. Second, as the grand challenges discourse is rooted in the sphere of sports and competition, it introduces a specific new set of societal values and practices into the spheres of science and technology. The article concludes that this process can be characterized as the sportification of science, which contributes to self-mobilization and, ultimately, to self-optimization of the participating scientists, engineers, and policymakers.
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Project description:BackgroundWe undertook a Grand Challenges in Global Eye Health prioritisation exercise to identify the key issues that must be addressed to improve eye health in the context of an ageing population, to eliminate persistent inequities in health-care access, and to mitigate widespread resource limitations.MethodsDrawing on methods used in previous Grand Challenges studies, we used a multi-step recruitment strategy to assemble a diverse panel of individuals from a range of disciplines relevant to global eye health from all regions globally to participate in a three-round, online, Delphi-like, prioritisation process to nominate and rank challenges in global eye health. Through this process, we developed both global and regional priority lists.FindingsBetween Sept 1 and Dec 12, 2019, 470 individuals complete round 1 of the process, of whom 336 completed all three rounds (round 2 between Feb 26 and March 18, 2020, and round 3 between April 2 and April 25, 2020) 156 (46%) of 336 were women, 180 (54%) were men. The proportion of participants who worked in each region ranged from 104 (31%) in sub-Saharan Africa to 21 (6%) in central Europe, eastern Europe, and in central Asia. Of 85 unique challenges identified after round 1, 16 challenges were prioritised at the global level; six focused on detection and treatment of conditions (cataract, refractive error, glaucoma, diabetic retinopathy, services for children and screening for early detection), two focused on addressing shortages in human resource capacity, five on other health service and policy factors (including strengthening policies, integration, health information systems, and budget allocation), and three on improving access to care and promoting equity.InterpretationThis list of Grand Challenges serves as a starting point for immediate action by funders to guide investment in research and innovation in eye health. It challenges researchers, clinicians, and policy makers to build collaborations to address specific challenges.FundingThe Queen Elizabeth Diamond Jubilee Trust, Moorfields Eye Charity, National Institute for Health Research Moorfields Biomedical Research Centre, Wellcome Trust, Sightsavers, The Fred Hollows Foundation, The Seva Foundation, British Council for the Prevention of Blindness, and Christian Blind Mission.TranslationsFor the French, Spanish, Chinese, Portuguese, Arabic and Persian translations of the abstract see Supplementary Materials section.
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