Ontology highlight
ABSTRACT:
SUBMITTER: Mukhopadhyay H
PROVIDER: S-EPMC3610635 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Mukhopadhyay Himadri H Cordoba Shaun-Paul SP Maini Philip K PK van der Merwe P Anton PA Dushek Omer O
PLoS computational biology 20130328 3
Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on multiple immunoreceptor tyrosine-based activation motifs (ITAMs). Intriguingly, Lck sequentially phosphorylates ITAMs and ZAP-70, a cytosolic kinase, binds to phosphorylated ITAMs with differential affin ...[more]