Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.
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ABSTRACT:
SUBMITTER: Raymond M
PROVIDER: S-EPMC361401 | biostudies-other | 1990 Nov
REPOSITORIES: biostudies-other
Publications
Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.
Molecular and cellular biology 19901101 11
To define cis-acting elements implicated in transcriptional regulation of the mouse multidrug resistance gene mdr1, we have cloned and characterized the 5' end of the gene. Nucleotide sequence analysis identified TATA, GGGCGG, and CCAAT consensus sequence elements at positions -27, -47, and -83, respectively. The transcriptional activities of 5' deletion fragments from the promoter linked to a reporter gene were tested in mouse cell lines of different tissue origins shown to express different le ...[more]
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