Ontology highlight
ABSTRACT:
SUBMITTER: Giacometti RD
PROVIDER: S-EPMC3618612 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Giacometti Robert D RD Duchek Jan J Werner Lukas L Husni Afeef S AS McCurdy Christopher R CR Cutler Stephen J SJ Cox D Phillip DP Hudlicky Tomas T
The Journal of organic chemistry 20130306 7
Heteroatom analogues of hydrocodone, in which the N-methyl functionality was replaced with oxygen, sulfur, sulfoxide, and sulfone, were prepared by a short sequence from the ethylene glycol ketal of hydrocodone; a carbocyclic analogue of bisnorhydrocodone was also prepared. The compounds were tested for receptor binding and revealed moderate levels of activity for the sulfone analogue of hydrocodone. ...[more]