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Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric ?-galactosyl ceramide analogues.

ABSTRACT: A library of dimeric CD1d ligands, containing two ?-galactosyl ceramide (?-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6"-azido-6"-deoxy-?-galactosyl ceramide derivative and various diynes. Each ?-GalCer dimer was tested for its ability to stimulate iNKT cells.

SUBMITTER: Jervis PJ

PROVIDER: S-EPMC3413882 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.

Jervis Peter J PJ Moulis Marie M Jukes John-Paul JP Ghadbane Hemza H Cox Liam R LR Cerundolo Vincenzo V Besra Gurdyal S GS

Carbohydrate research 20120307

A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6"-azido-6"-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells. ...[more]

PMID: 22445102

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