Ontology highlight
ABSTRACT:
SUBMITTER: Lum LS
PROVIDER: S-EPMC362949 | biostudies-other | 1990 Dec
REPOSITORIES: biostudies-other
Lum L S LS Sultzman L A LA Kaufman R J RJ Linzer D I DI Wu B J BJ
Molecular and cellular biology 19901201 12
The basal promoter of the human hsp70 gene is predominantly controlled by a CCAAT element at position -70 relative to the transcriptional initiation site. We report the isolation of a novel cDNA clone encoding a 114-kDa polypeptide that binds to the CCAAT element of the hsp70 promoter. Expression of this CCAAT-binding factor (CBF) cDNA activated transcription from cotransfected hsp70 promoter-reporter gene constructs in a CCAAT-dependent manner. CCAAT-binding factor shows no homology to the prev ...[more]