Ontology highlight
ABSTRACT:
SUBMITTER: Aboussekhra A
PROVIDER: S-EPMC364537 | biostudies-other | 1992 Jul
REPOSITORIES: biostudies-other
Aboussekhra A A Chanet R R Adjiri A A Fabre F F
Molecular and cellular biology 19920701 7
Eleven suppressors of the radiation sensitivity of Saccharomyces cerevisiae diploids lacking the Srs2 helicase were analyzed and found to contain codominant mutations in the RAD51 gene known to be involved in recombinational repair and in genetic recombination. These mutant alleles confer an almost complete block in recombinational repair, as does deletion of RAD51, but heterozygous mutant alleles suppress the defects of srs2::LEU2 cells and are semidominant in Srs2+ cells. The results of this s ...[more]