Ontology highlight
ABSTRACT:
SUBMITTER: Coccia EM
PROVIDER: S-EPMC364604 | biostudies-other | 1992 Aug
REPOSITORIES: biostudies-other
Coccia E M EM Cicala C C Charlesworth A A Ciccarelli C C Rossi G B GB Philipson L L Sorrentino V V
Molecular and cellular biology 19920801 8
The growth arrest-specific gas5 gene was isolated from mouse genomic DNA and structurally characterized. The transcriptional unit is divided into 12 exons that span around 7 kb. An alternative splicing mechanism gives rise to two mature mRNAs which contain either 11 or 12 exons, and both are found in the cytoplasm of growth-arrested cells. In vivo, the gas5 gene is ubiquitously expressed in mouse tissues during development and adult life. In Friend leukemia and NIH 3T3 cells, the levels of gas5 ...[more]