Ontology highlight
ABSTRACT:
SUBMITTER: Takats S
PROVIDER: S-EPMC3653357 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
Takáts Szabolcs S Nagy Péter P Varga Ágnes Á Pircs Karolina K Kárpáti Manuéla M Varga Kata K Kovács Attila L AL Hegedűs Krisztina K Juhász Gábor G
The Journal of cell biology 20130501 4
During autophagy, phagophores capture portions of cytoplasm and form double-membrane autophagosomes to deliver cargo for lysosomal degradation. How autophagosomes gain competence to fuse with late endosomes and lysosomes is not known. In this paper, we show that Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster. Loss of these genes results in accumulation of autophagosomes and a b ...[more]