Ontology highlight
ABSTRACT:
SUBMITTER: Palanimuthu A
PROVIDER: S-EPMC9051536 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Palanimuthu Arunan A Chen Chinpiao C Lee Gene-Hsian GH
RSC advances 20200403 23
A three-component cascade reaction involving 2-alkenyl aniline, aldehydes, and ethyl cyanoacetate in the presence of DBU to synthesize highly substituted 1,2,3,4-tetrahydroquinolines is reported. The reaction proceeded through the Knoevenagel condensation of ethyl cyanoacetate with aldehydes followed by the aza-Michael-Michael addition with 2-alkenyl anilines to prepare the tetrahydroquinoline scaffolds. ...[more]