Ontology highlight
ABSTRACT:
SUBMITTER: Mike LA
PROVIDER: S-EPMC3657828 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20130429 20
Staphylococcus aureus is a significant infectious threat to global public health. Acquisition or synthesis of heme is required for S. aureus to capture energy through respiration, but an excess of this critical cofactor is toxic to bacteria. S. aureus employs the heme sensor system (HssRS) to overcome heme toxicity; however, the mechanism of heme sensing is not defined. Here, we describe the identification of a small molecule activator of HssRS that induces endogenous heme biosynthesis by pertur ...[more]