Ontology highlight
ABSTRACT:
SUBMITTER: Zheng KW
PROVIDER: S-EPMC3664831 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
Zheng Ke-wei KW Xiao Shan S Liu Jia-quan JQ Zhang Jia-yu JY Hao Yu-hua YH Tan Zheng Z
Nucleic acids research 20130412 10
G-quadruplex formation in genomic DNA is considered to regulate transcription. Previous investigations almost exclusively focused on intramolecular G-quadruplexes formed by DNA carrying four or more G-tracts, and structure formation has rarely been studied in physiologically relevant processes. Here, we report an almost entirely neglected, but actually much more prevalent form of G-quadruplexes, DNA:RNA hybrid G-quadruplexes (HQ) that forms in transcription. HQ formation requires as few as two G ...[more]