RNA-guided genome editing a la carte.
Ontology highlight
ABSTRACT: Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.
SUBMITTER: Horvath P
PROVIDER: S-EPMC3674385 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
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