Ontology highlight
ABSTRACT:
SUBMITTER: Choi J
PROVIDER: S-EPMC3677452 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20130520 23
The regulatory protein PmrA controls expression of lipopolysaccharide (LPS) modification genes in Salmonella enterica serovar Typhimurium, the etiologic agent of human gastroenteritis and murine typhoid fever. PmrA-dependent LPS modifications confer resistance to serum, Fe(3+), and several antimicrobial peptides, suggesting that the pmrA gene is required for Salmonella virulence. We now report that, surprisingly, a pmrA null mutant is actually hypervirulent when inoculated i.p. into C3H/HeN mice ...[more]