Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura K
PROVIDER: S-EPMC3677504 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Nakamura Kyohei K Nakayama Masafumi M Kawano Mitsuko M Amagai Ryo R Ishii Tomonori T Harigae Hideo H Ogasawara Kouetsu K
Proceedings of the National Academy of Sciences of the United States of America 20130520 23
The natural killer group 2 membrane D (NKG2D) activating receptor plays crucial roles not only in host defense against tumors and viral infections, but also in autoimmune diseases. After NKG2D-mediated activation, Natural killer (NK) cells must be regulated to avoid potentially harmful reactivity. However, the negative regulation of these activated NK cells is poorly understood. Here, we reveal that the engagement of NKG2D by its ligand elicits not only target cell lysis, but also NK cell fratri ...[more]