Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.
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ABSTRACT:
SUBMITTER: Kundu R
PROVIDER: S-EPMC3677582 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Publications
Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.
Kundu Rituparna R Cushing Patrick R PR Popp Brian V BV Zhao Yu Y Madden Dean R DR Ball Zachary T ZT
Angewandte Chemie (International ed. in English) 20120614 29
Together strong: Cooperative binding of organic (see picture, red) and inorganic fragments provides a strategy for the potent inhibition of protein-protein interactions. By targeting specific Lewis basic side chains in peripheral regions of the binding site for coordination to a rhodium(II) center, the affinity of otherwise weak ligands is improved. ...[more]
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