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General and facile surface functionalization of hydrophobic nanocrystals with poly(amino acid) for cell luminescence imaging.

ABSTRACT: Hydrophobic nanocrystals with various shape, size, and chemical composition were successfully functionalized by poly(amino acid) with one particle per micelle without aggregation or precipitation via a facile, general, and low-cost strategy. Via simply tuning the pH value, multifunctional nanocomposites consisting of different nanocrystals were also fabricated. Due to the poly(amino acid) coating, these nanocrystals are highly water-stable, biocompatible, and bioconjugatable with chemical and biological moieties. Meanwhile, their shape, size, optical/magnetic properties are well retained, which is highly desirable for bioapplications. This developed strategy presents a novel opportunity to apply hydrophobic nanocrystals to various biomedical fields.

SUBMITTER: Huang S

PROVIDER: S-EPMC3685825 | biostudies-other | 2013

REPOSITORIES: biostudies-other

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General and facile surface functionalization of hydrophobic nanocrystals with poly(amino acid) for cell luminescence imaging.

Huang Sheng S Bai Min M Wang Leyu L

Scientific reports 20130101

Hydrophobic nanocrystals with various shape, size, and chemical composition were successfully functionalized by poly(amino acid) with one particle per micelle without aggregation or precipitation via a facile, general, and low-cost strategy. Via simply tuning the pH value, multifunctional nanocomposites consisting of different nanocrystals were also fabricated. Due to the poly(amino acid) coating, these nanocrystals are highly water-stable, biocompatible, and bioconjugatable with chemical and bi ...[more]

PMID: 23778122

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