Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging.
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ABSTRACT:
SUBMITTER: Andersson DC
PROVIDER: S-EPMC3690519 | biostudies-other | 2011 Aug
REPOSITORIES: biostudies-other
Publications
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging.
Andersson Daniel C DC Betzenhauser Matthew J MJ Reiken Steven S Meli Albano C AC Umanskaya Alisa A Xie Wenjun W Shiomi Takayuki T Zalk Ran R Lacampagne Alain A Marks Andrew R AR
Cell metabolism 20110801 2
Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and depleted of the channel-stabilizing subunit calstabin1, compared to RyR1 from younger (3-6 months) adults. This RyR1 channel complex remodeling resulted in "leaky" channels with increased ...[more]
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