Ontology highlight
ABSTRACT:
SUBMITTER: O'Leary T
PROVIDER: S-EPMC3710808 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
O'Leary Timothy T Williams Alex H AH Caplan Jonathan S JS Marder Eve E
Proceedings of the National Academy of Sciences of the United States of America 20130624 28
Experimental observations reveal that the expression levels of different ion channels vary across neurons of a defined type, even when these neurons exhibit stereotyped electrical properties. However, there are robust correlations between different ion channel expression levels, although the mechanisms that determine these correlations are unknown. Using generic model neurons, we show that correlated conductance expression can emerge from simple homeostatic control mechanisms that couple express ...[more]