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Kinase detection with gallium nitride based high electron mobility transistors.


ABSTRACT: A label-free kinase detection system was fabricated by the adsorption of gold nanoparticles functionalized with kinase inhibitor onto AlGaN/GaN high electron mobility transistors (HEMTs). The HEMTs were operated near threshold voltage due to the greatest sensitivity in this operational region. The Au NP/HEMT biosensor system electrically detected 1 pM SRC kinase in ionic solutions. These results are pertinent to drug development applications associated with kinase sensing.

SUBMITTER: Makowski MS 

PROVIDER: S-EPMC3716718 | biostudies-other | 2013 Jul

REPOSITORIES: biostudies-other

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