Ontology highlight
ABSTRACT:
SUBMITTER: Han A
PROVIDER: S-EPMC3740842 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Han Arnold A Newell Evan W EW Glanville Jacob J Fernandez-Becker Nielsen N Khosla Chaitan C Chien Yueh-Hsiu YH Davis Mark M MM
Proceedings of the National Academy of Sciences of the United States of America 20130722 32
Celiac disease is an intestinal autoimmune disease driven by dietary gluten and gluten-specific CD4(+) T-cell responses. In celiac patients on a gluten-free diet, exposure to gluten induces the appearance of gluten-specific CD4(+) T cells with gut-homing potential in the peripheral blood. Here we show that gluten exposure also induces the appearance of activated, gut-homing CD8(+) αβ and γδ T cells in the peripheral blood. Single-cell T-cell receptor sequence analysis indicates that both of thes ...[more]